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Analgesic Potential of Sesquiterpenes Derived from Agarwood in Recurrent Aphthous Ulcer

Received: 6 November 2022    Accepted: 17 November 2022    Published: 29 November 2022
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Abstract

Background: Oral Aphthous ulcer (RAU) is a common oral mucosal disease, often accompanied by pain affecting eating. In the past, the treatment of RAU has focused on pain relief, but there is no specific drug to treat RAU. Agarwood is one of the most commonly used traditional Chinese medicinal materials in clinic. Pharmacological studies have confirmed that the active ingredient sesquiterpene of agarwood has the effect of relieving pain. Objectives: To explore the mechanism of agarwood in relieving pain of RAU. Methods: The research progress of agarwood in relieving pain was reviewed by referring to the relevant literatures at home and abroad in recent years. Results: The active ingredient sesquiterpene of agarwood relieved the pain symptoms of RAU by affecting the expression of neurotransmitters. The sesquiterpenoids of agarwood can affect the expression of neurotransmitters by regulating the expression of γ-Aminobutyric Acid (GABA), Serotonin (5-HT) and Nitric Oxide (NO) in the nervous system. Based on these, agarwood sesquiterpene has good analgesic effect. Conclusion: Agarwood sesquiterpenoids can relieve pain symptoms of RAU. The role of sesquiterpene in the regulation of neurotransmitters makes it promising to be used as a special drug to relieve the pain and promote the healing of RAU.

Published in Pharmaceutical Science and Technology (Volume 6, Issue 2)
DOI 10.11648/j.pst.20220602.12
Page(s) 26-29
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Agarwood, Recurrent Aphthous Ulcer, Sesquiterpene, Pain, Neurotransmitter

References
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[2] Tan CS, Isa NM, Ismail I, Zainal Z. Agarwood Induction: Current Developments and Future Perspectives. Front Plant Sci. 2019; 10: 122.
[3] Wang Q, Shang LL, Yan TT, et al. HPLC fingerprint characteristics of agarwood from different habitats [J]. Scientia Silvae Sinicae, 2021, 57 (2): 150-159.
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[17] Wang Ch, Wang S, Peng DQ, et al. Prediction and Analysis of the Components and Therapeutic Targets of Agarwood Essential Oil. Chin Pharm J, 2019, 54 (23): 1958-1964.
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Cite This Article
  • APA Style

    Si-Yu Tao, Jing-Kai Fu, Sunchuri Diwas, Yi-Nan Zhang, Nan Wang, et al. (2022). Analgesic Potential of Sesquiterpenes Derived from Agarwood in Recurrent Aphthous Ulcer. Pharmaceutical Science and Technology, 6(2), 26-29. https://doi.org/10.11648/j.pst.20220602.12

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    ACS Style

    Si-Yu Tao; Jing-Kai Fu; Sunchuri Diwas; Yi-Nan Zhang; Nan Wang, et al. Analgesic Potential of Sesquiterpenes Derived from Agarwood in Recurrent Aphthous Ulcer. Pharm. Sci. Technol. 2022, 6(2), 26-29. doi: 10.11648/j.pst.20220602.12

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    AMA Style

    Si-Yu Tao, Jing-Kai Fu, Sunchuri Diwas, Yi-Nan Zhang, Nan Wang, et al. Analgesic Potential of Sesquiterpenes Derived from Agarwood in Recurrent Aphthous Ulcer. Pharm Sci Technol. 2022;6(2):26-29. doi: 10.11648/j.pst.20220602.12

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  • @article{10.11648/j.pst.20220602.12,
      author = {Si-Yu Tao and Jing-Kai Fu and Sunchuri Diwas and Yi-Nan Zhang and Nan Wang and Yao Yao and Fan-Di Xu and Yang Lin and Zhu-Ling Guo},
      title = {Analgesic Potential of Sesquiterpenes Derived from Agarwood in Recurrent Aphthous Ulcer},
      journal = {Pharmaceutical Science and Technology},
      volume = {6},
      number = {2},
      pages = {26-29},
      doi = {10.11648/j.pst.20220602.12},
      url = {https://doi.org/10.11648/j.pst.20220602.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.pst.20220602.12},
      abstract = {Background: Oral Aphthous ulcer (RAU) is a common oral mucosal disease, often accompanied by pain affecting eating. In the past, the treatment of RAU has focused on pain relief, but there is no specific drug to treat RAU. Agarwood is one of the most commonly used traditional Chinese medicinal materials in clinic. Pharmacological studies have confirmed that the active ingredient sesquiterpene of agarwood has the effect of relieving pain. Objectives: To explore the mechanism of agarwood in relieving pain of RAU. Methods: The research progress of agarwood in relieving pain was reviewed by referring to the relevant literatures at home and abroad in recent years. Results: The active ingredient sesquiterpene of agarwood relieved the pain symptoms of RAU by affecting the expression of neurotransmitters. The sesquiterpenoids of agarwood can affect the expression of neurotransmitters by regulating the expression of γ-Aminobutyric Acid (GABA), Serotonin (5-HT) and Nitric Oxide (NO) in the nervous system. Based on these, agarwood sesquiterpene has good analgesic effect. Conclusion: Agarwood sesquiterpenoids can relieve pain symptoms of RAU. The role of sesquiterpene in the regulation of neurotransmitters makes it promising to be used as a special drug to relieve the pain and promote the healing of RAU.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Analgesic Potential of Sesquiterpenes Derived from Agarwood in Recurrent Aphthous Ulcer
    AU  - Si-Yu Tao
    AU  - Jing-Kai Fu
    AU  - Sunchuri Diwas
    AU  - Yi-Nan Zhang
    AU  - Nan Wang
    AU  - Yao Yao
    AU  - Fan-Di Xu
    AU  - Yang Lin
    AU  - Zhu-Ling Guo
    Y1  - 2022/11/29
    PY  - 2022
    N1  - https://doi.org/10.11648/j.pst.20220602.12
    DO  - 10.11648/j.pst.20220602.12
    T2  - Pharmaceutical Science and Technology
    JF  - Pharmaceutical Science and Technology
    JO  - Pharmaceutical Science and Technology
    SP  - 26
    EP  - 29
    PB  - Science Publishing Group
    SN  - 2640-4540
    UR  - https://doi.org/10.11648/j.pst.20220602.12
    AB  - Background: Oral Aphthous ulcer (RAU) is a common oral mucosal disease, often accompanied by pain affecting eating. In the past, the treatment of RAU has focused on pain relief, but there is no specific drug to treat RAU. Agarwood is one of the most commonly used traditional Chinese medicinal materials in clinic. Pharmacological studies have confirmed that the active ingredient sesquiterpene of agarwood has the effect of relieving pain. Objectives: To explore the mechanism of agarwood in relieving pain of RAU. Methods: The research progress of agarwood in relieving pain was reviewed by referring to the relevant literatures at home and abroad in recent years. Results: The active ingredient sesquiterpene of agarwood relieved the pain symptoms of RAU by affecting the expression of neurotransmitters. The sesquiterpenoids of agarwood can affect the expression of neurotransmitters by regulating the expression of γ-Aminobutyric Acid (GABA), Serotonin (5-HT) and Nitric Oxide (NO) in the nervous system. Based on these, agarwood sesquiterpene has good analgesic effect. Conclusion: Agarwood sesquiterpenoids can relieve pain symptoms of RAU. The role of sesquiterpene in the regulation of neurotransmitters makes it promising to be used as a special drug to relieve the pain and promote the healing of RAU.
    VL  - 6
    IS  - 2
    ER  - 

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Author Information
  • School of Dentistry, Hainan Medical University, Haikou, PR China

  • School of Dentistry, Hainan Medical University, Haikou, PR China

  • School of International Education, Hainan Medical University, Haikou, PR China

  • School of Dentistry, Hainan Medical University, Haikou, PR China

  • School of Dentistry, Hainan Medical University, Haikou, PR China

  • School of Dentistry, Hainan Medical University, Haikou, PR China

  • School of Dentistry, Hainan Medical University, Haikou, PR China

  • School of Dentistry, Hainan Medical University, Haikou, PR China

  • School of Dentistry, Hainan Medical University, Haikou, PR China; Department of Health Management Center, The First Affiliated Hospital of Hainan Medical University, Haikou, PR China

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