Volume 3, Issue 1, June 2019, Page: 27-33
Pharmacological Study on a Potential Medicinal Herb-Foeniculum vulgare
Md. Ruhul Amin, Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh
Md. Abdullah-Al-Masum, Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh; Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh
Asma Kabir, Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh; Pratyasha Health Biomedical Research Center, Dhaka, Bangladesh
Tofazzal Hossain Rubel, Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh
Md. Omar Faruqe, Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh
Md. Shahadat Hossain, Department of Applied Chemistry and Chemical Engineering, Noakhali Science and Technology University, Noakhali, Bangladesh
Md Abu Torab, Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh
Md. Afjal Hossain, Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh
Md. Shahadat Hossain, Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh
Shafayet Ahmed Siddiqui, Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh
Received: Aug. 2, 2019;       Accepted: Aug. 21, 2019;       Published: Sep. 3, 2019
DOI: 10.11648/j.pst.20190301.14      View  103      Downloads  9
Abstract
This study was conducted to investigate the antiemetic, antimicrobial and anti-radical activity of methanolic extracts of Foeniculum vulgare. The antiemetic assay was carried out by using chick emetic model with minor modifications by calculating the mean decrease in the number of retching. The antimicrobial activity of the crude extract was performed by Disc Diffusion method. The anti-radical activity was determined by the 2, 2-diphenyl-2-picrylhydrazyl hydrate (DPPH) method. The anti-emetic activity of Foeniculum vulgare leaves on young chicks revealed that these extracts have a less anti-emetic effect. The group of chicks treated with Chlorpromazine was found to have 60.6 retches as compared to the 66 retches of the control group, thus Chlorpromazine reduced the retches by 7.93%. The chickens treated with leaves extracts inhibited the retches up to 2.03%. The minimum antimicrobial effect was found in this methanol crude extract. The extract did not appear potent in terms of both zones of inhibition and spectrum of activity. In anti-radical activity test, the extract showed moderate free radical scavenging activity with IC50 value 240.39μg/ml. while compared to that of the reference standard ascorbic acid. Methanolic extract of Foeniculum vulgare leaves have minimum anti-emetic and anti-microbial activities and moderate anti-radical properties.
Keywords
Antiemetic, Antimicrobial, Antioxidant, Foeniculum vulgare
To cite this article
Md. Ruhul Amin, Md. Abdullah-Al-Masum, Asma Kabir, Tofazzal Hossain Rubel, Md. Omar Faruqe, Md. Shahadat Hossain, Md Abu Torab, Md. Afjal Hossain, Md. Shahadat Hossain, Shafayet Ahmed Siddiqui, Pharmacological Study on a Potential Medicinal Herb-Foeniculum vulgare, Pharmaceutical Science and Technology. Vol. 3, No. 1, 2019, pp. 27-33. doi: 10.11648/j.pst.20190301.14
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Reference
[1]
Rashed-Al-Qayum KMD, Moghal MMR, Amin MN, Hossain MS, Hossain MD. Analgesic and antipyretic activities of two medicinal plants-Salvinia minima and Dactyloctenium australe in experimental animal models. Der Pharm Sin 2013; 4: 183–7.
[2]
Kalemba D, Kunicka A. Antibacterial and antifungal properties of essential oils. Curr Med Chem 2003; 10: 813–29.
[3]
Rios JL, Recio MC. Medicinal plants and antimicrobial activity. J Ethnopharmacol 2005; 100: 80–4.
[4]
Amin MN, Banik S, Ibrahim M, Moghal MMR, Majumder MS, Siddika R, et al. A study on Ardisia solanacea for evaluation of phytochemical and pharmacological properties. Carbon N Y 2015; 250: 0–348.
[5]
Uddin SMN, Amin MN, Shahid-Ud-Daula AFM, Hossain H, Haque MM, Rahman MS, et al. Phytochemical screening and study of antioxidant and analgesic potentials of ethanolic extract of Stephania japonica Linn. J Med Plants Res 2014; 8: 1127–33.
[6]
Raju GS, Moghal MR, Dewan SMR, Amin MN, Billah M. Characterization of phytoconstituents and evaluation of total phenolic content, anthelmintic, and antimicrobial activities of Solanum violaceum Ortega. Avicenna J Phytomedicine 2013; 3: 313.
[7]
Emran T Bin, Ahmed S, Zahan S, Rakib A, Hasan MS, Amin MN, et al. Sedative, Anxiolytic, Antinociceptive, Anti-inflammatory and Antipyretic Effects of a Chloroform Extract from the Leaves of Urena sinuata in Rodents. J Appl Life Sci Int 2018: 1–19.
[8]
Ahmad I, Mehmood Z, Mohammad F. Screening of some Indian medicinal plants for their antimicrobial properties. J Ethnopharmacol 1998; 62: 183–93.
[9]
Singh G, Maurya S, De Lampasona MP, Catalan C. Chemical constituents, antifungal and antioxidative potential of Foeniculum vulgare volatile oil and its acetone extract. Food Control 2006; 17: 745–52.
[10]
Prajapati V, Tripathi AK, Aggarwal KK, Khanuja SPS. Insecticidal, repellent and oviposition-deterrent activity of selected essential oils against Anopheles stephensi, Aedes aegypti and Culex quinquefasciatus. Bioresour Technol 2005; 96: 1749–57.
[11]
Prestinaci F, Pezzotti P, Pantosti A. Antimicrobial resistance: a global multifaceted phenomenon. Pathog Glob Health 2015; 109: 309–18.
[12]
Purkayastha S, Narain R, Dahiya P. Evaluation of antimicrobial and phytochemical screening of Fennel, Juniper and Kalonji essential oils against multi drug resistant clinical isolates. Asian Pac J Trop Biomed 2012; 2: S1625–9.
[13]
Essawi T, Srour M. Screening of some Palestinian medicinal plants for antibacterial activity. J Ethnopharmacol 2000; 70: 343–9.
[14]
Spellberg B, Powers JH, Brass EP, Miller LG, Edwards Jr JE. Trends in antimicrobial drug development: implications for the future. Clin Infect Dis 2004; 38: 1279–86.
[15]
Liu CH, Mishra AK, Tan RX, Tang C, Yang H, Shen YF. Repellent and insecticidal activities of essential oils from Artemisia princeps and Cinnamomum camphora and their effect on seed germination of wheat and broad bean. Bioresour Technol 2006; 97: 1969–73.
[16]
Davies KJA. Oxidative stress: the paradox of aerobic life. Biochem. Soc. Symp., vol. 61, Portland Press Limited; 1995, p. 1–31.
[17]
El-Hawary SA, Sokkar NM, Ali ZY, Yehia MM. A profile of bioactive compounds of Rumex vesicarius L. J Food Sci 2011; 76: C1195–202.
[18]
Dewan SMR, Amin MN, Adnan T, Uddin SMN, Shahid-Ud-Daula AFM, Sarwar G, et al. Investigation of analgesic potential and in vitro antioxidant activity of two plants of Asteraceae family growing in Bangladesh. J Pharm Res 2013; 6: 599–603.
[19]
Hossain MS, Tuly FA, Akter S, Arman MSI, Aziz MA, Mahmud ME, et al. Determination of Antiemetic, Antimicrobial, Anti-Radical and Cytotoxic Activity of Methanolic Extracts of Centella asiatica. Plant 2018; 6: 1–7.
[20]
Iqbal S, Bhanger MI, Anwar F. Antioxidant properties and components of bran extracts from selected wheat varieties commercially available in Pakistan. LWT-Food Sci Technol 2007; 40: 361–7.
[21]
Stanner SA, Hughes J, Kelly CNM, Buttriss J. A review of the epidemiological evidence for the ‘antioxidant hypothesis. ’ Public Health Nutr 2004; 7: 407–22.
[22]
Barros L, Carvalho AM, Ferreira ICFR. The nutritional composition of fennel (Foeniculum vulgare): Shoots, leaves, stems and inflorescences. LWT-Food Sci Technol 2010; 43: 814–8.
[23]
Rather MA, Dar BA, Sofi SN, Bhat BA, Qurishi MA. Foeniculum vulgare: A comprehensive review of its traditional use, phytochemistry, pharmacology, and safety. Arab J Chem 2016; 9: S1574–83.
[24]
Damjanović B, Lepojević Ž, Živković V, Tolić A. Extraction of fennel (Foeniculum vulgare Mill.) seeds with supercritical CO2: Comparison with hydrodistillation. Food Chem 2005; 92: 143–9.
[25]
Muckensturm B, Foechterlen D, Reduron J-P, Danton P, Hildenbrand M. Phytochemical and chemotaxonomic studies of Foeniculum vulgare. Biochem Syst Ecol 1997; 25: 353–8.
[26]
Moghtader M. Comparative survey on the essential oil composition from the seeds and flowers of Foeniculum vulgare Mill. from Kerman province. J Hortic For 2013; 5: 37–40.
[27]
Chaouche T, Haddouchi F, Lazouni HA, Bekkara FA. Phytochemicalstudyof theplant foeniculum vulgare mill. Der Pharm Lett 2011; 3: 329–33.
[28]
Akgül A, Bayrak A. Comparative volatile oil composition of various parts from Turkish bitter fennel (Foeniculum vulgare var. vulgare). Food Chem 1988; 30: 319–23.
[29]
Díaz-Maroto MC, Díaz-Maroto Hidalgo IJ, Sánchez-Palomo E, Pérez-Coello MS. Volatile components and key odorants of Fennel (Foeniculum vulgare Mill.) and Thyme (Thymus vulgaris L.) oil extracts obtained by simultaneous distillation− extraction and supercritical fluid extraction. J Agric Food Chem 2005; 53: 5385–9.
[30]
Saviuc C, Marinas I, Grumezescu AM, Bleotu C, Chifiriuc C, Mihaiescu D, et al. Phytochemical composition of the fennel fruits essential oil and its influence on prokariotic cells growth and pathogenic features. Biointerface Res Appl Chem 2012; 2: 300–5.
[31]
Birdane FM, Cemek M, Birdane YO, Gülçin İ, Büyükokuroğlu ME. Beneficial effects of Foeniculum vulgare on ethanol-induced acute gastric mucosal injury in rats. World J Gastroenterol WJG 2007; 13: 607.
[32]
Kaur GJ, Arora DS. Antibacterial and phytochemical screening of Anethum graveolens, Foeniculum vulgare and Trachyspermum ammi. BMC Complement Altern Med 2009; 9: 30.
[33]
Khazaei M, Montaseri A, Khazaei MR, Khanahmadi M. Study of Foeniculum vulgare effect on folliculogenesis in female mice. Int J Fertil Steril 2011; 5: 122.
[34]
Koppula S, Kumar H. Foeniculum vulgare Mill (Umbelliferae) attenuates stress and improves memory in wister rats. Trop J Pharm Res 2013; 12: 553–8.
[35]
Akita Y, Yang Y, Kawai T, Kinoshita K, Koyama K, Takahashi K, et al. New assay method for surveying anti-emetic compounds from natural sources. Nat Prod Sci 1998; 4: 72–7.
[36]
Brand-Williams W, Cuvelier M-E, Berset C. Use of a free radical method to evaluate antioxidant activity. LWT-Food Sci Technol 1995; 28: 25–30.
[37]
Pittella F, Dutra R, Junior D, Lopes MT, Barbosa N. Antioxidant and cytotoxic activities of Centella asiatica (L) Urb. Int J Mol Sci 2009; 10: 3713–21.
[38]
Fang L, Qi M, Li T, Shao Q, Fu R. Headspace solvent microextraction-gas chromatography–mass spectrometry for the analysis of volatile compounds from Foeniculum vulgare Mill. J Pharm Biomed Anal 2006; 41: 791–7.
[39]
Zhao NN, Zhou L, Liu ZL, Du SS, Deng ZW. Evaluation of the toxicity of the essential oils of some common Chinese spices against Liposcelis bostrychophila. Food Control 2012; 26: 486–90.
[40]
Bano S, Ahmad N, Sharma AK. Phytochemical investigation and evaluation of anti-microbial and anti-oxidant activity of Foeniculum vulgare (fennel). Int J Pharma Sci Res 2016; 7: 310–4.
[41]
Foroughi A, Pournaghi P, Zhaleh M, Zangeneh A, Zangeneh MM, Moradi R. Antibacterial activity and phytochemical screening of essential oil of Foeniculum vulgare. Int J Pharm Clin Res 2016; 8: 1505–9.
[42]
Beyazen A, Dessalegn E, Mamo W. Phytochemical screening and biological activities of leaf of Foeniculum vulgare (Ensilal). Int J Chem Stud 2017; 5: 18–25.
Browse journals by subject