Volume 3, Issue 1, June 2019, Page: 27-33
Pharmacological Study on a Potential Medicinal Herb-Foeniculum vulgare
Md. Ruhul Amin, Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh
Md. Abdullah-Al-Masum, Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh; Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh
Asma Kabir, Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh; Pratyasha Health Biomedical Research Center, Dhaka, Bangladesh
Tofazzal Hossain Rubel, Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh
Md. Omar Faruqe, Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh
Md. Shahadat Hossain, Department of Applied Chemistry and Chemical Engineering, Noakhali Science and Technology University, Noakhali, Bangladesh
Md Abu Torab, Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh
Md. Afjal Hossain, Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh
Md. Shahadat Hossain, Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh
Shafayet Ahmed Siddiqui, Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh
Received: Aug. 2, 2019;       Accepted: Aug. 21, 2019;       Published: Sep. 3, 2019
DOI: 10.11648/j.pst.20190301.14      View  697      Downloads  148
This study was conducted to investigate the antiemetic, antimicrobial and anti-radical activity of methanolic extracts of Foeniculum vulgare. The antiemetic assay was carried out by using chick emetic model with minor modifications by calculating the mean decrease in the number of retching. The antimicrobial activity of the crude extract was performed by Disc Diffusion method. The anti-radical activity was determined by the 2, 2-diphenyl-2-picrylhydrazyl hydrate (DPPH) method. The anti-emetic activity of Foeniculum vulgare leaves on young chicks revealed that these extracts have a less anti-emetic effect. The group of chicks treated with Chlorpromazine was found to have 60.6 retches as compared to the 66 retches of the control group, thus Chlorpromazine reduced the retches by 7.93%. The chickens treated with leaves extracts inhibited the retches up to 2.03%. The minimum antimicrobial effect was found in this methanol crude extract. The extract did not appear potent in terms of both zones of inhibition and spectrum of activity. In anti-radical activity test, the extract showed moderate free radical scavenging activity with IC50 value 240.39μg/ml. while compared to that of the reference standard ascorbic acid. Methanolic extract of Foeniculum vulgare leaves have minimum anti-emetic and anti-microbial activities and moderate anti-radical properties.
Antiemetic, Antimicrobial, Antioxidant, Foeniculum vulgare
To cite this article
Md. Ruhul Amin, Md. Abdullah-Al-Masum, Asma Kabir, Tofazzal Hossain Rubel, Md. Omar Faruqe, Md. Shahadat Hossain, Md Abu Torab, Md. Afjal Hossain, Md. Shahadat Hossain, Shafayet Ahmed Siddiqui, Pharmacological Study on a Potential Medicinal Herb-Foeniculum vulgare, Pharmaceutical Science and Technology. Vol. 3, No. 1, 2019, pp. 27-33. doi: 10.11648/j.pst.20190301.14
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This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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