Volume 4, Issue 1, June 2020, Page: 1-10
Novel Long Retentive Posaconazole Ophthalmic Suspension
Jadhav Simta, Department of Pharmaceutical Chemistry, C. U. Shah College of Pharmacy, Mumbai, India
Inamdar Kavita, Department of Pharmaceutical Chemistry, C. U. Shah College of Pharmacy, Mumbai, India
Bhitre Milind, Department of Pharmaceutical Chemistry, C. U. Shah College of Pharmacy, Mumbai, India
Received: Dec. 20, 2019;       Accepted: Jan. 3, 2020;       Published: Feb. 14, 2020
DOI: 10.11648/j.pst.20200401.11      View  331      Downloads  133
Abstract
Ophthalmic formulations are not completely available for eliciting therapeutic action because of various reasons such as rapid tear drainage, blinking of eye, lower residence time and lower cul de sac volume. Ophthalmic formulation gets easily drained off due to eye blinking due to low viscosity. Posaconazole is known to have antifungal efficacy as oral route, however ophthalmic efficacy is not studied. The objective of present work was to develop long retentive posaconazole ophthalmic suspension based on polymer platform system of carbopol 974 P and xanthan gum. This synergistic polymer platform was pre-identified by means of experimental design study. Polymer based formulation helps to retain the drug at the site of action for longer duration and does not get washed away due to eye blinking phenomenon. Sterilization is key parameters for ophthalmic formulation. Different methods of sterilization were studied for posaconazole drug as well as polymer mixture and finished product. The developed formulations were characterized for homogeneity, pH, particle size, viscosity, osmolality, rheology study, mucoadhesive strength, contact angle, assay of posaconazole and benzalkonium chloride, degradation product, polymorphic form evaluation, eye irritation test and pharmacodynamic efficacy study. A stable long retentive posaconazole ophthalmic formulation was developed based on principles of quality by design. The developed formulation can be easily manufactured at bigger scale without need of any sophisticated equipment.
Keywords
Ocular Long Retentive, Posaconazole, Ophthalmic Suspension
To cite this article
Jadhav Simta, Inamdar Kavita, Bhitre Milind, Novel Long Retentive Posaconazole Ophthalmic Suspension, Pharmaceutical Science and Technology. Vol. 4, No. 1, 2020, pp. 1-10. doi: 10.11648/j.pst.20200401.11
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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