Volume 4, Issue 1, June 2020, Page: 11-16
Evaluation of Liver Toxicity of Three Different Herbal Bitters (Confam, G. Winco and 1960 Roots) on Wister Albino Rats
George Adieboye Oforibika, Department of Science Laboratory Technology, School of Science and Technology, Captain Elechi Amadi Polytechnic, Port Harcourt, Nigeria
Diepiriye Adokiye Oforibika, Department of Medicine and Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria
Received: Jan. 7, 2020;       Accepted: Jan. 21, 2020;       Published: Feb. 14, 2020
DOI: 10.11648/j.pst.20200401.12      View  213      Downloads  70
Abstract
This study evaluates the liver toxicity of three different herbal bitters (G. Winco, 1960 roots and Confam) on Wister albino rats. A total of 40 rats were randomly divided into 4 groups labeled A, B, C and D and kept in a well ventilated room. Group A served as control and these rats were treated with distilled water. Wister albino rats in the groups B, C and D were treated with 3 different doses of the bitters (20, 30 and 40mL/Kgbw) respectively. The drugs were administered once daily for 10 and 21days consecutively. Animals were sacrificed 24 hours after the last treatment. Blood samples were collected into heparinized sample bottles for analysis. There was no significant difference in the results obtained. Alkaline phosphatase and aspartate transaminase was decreased in a non-dose dependent manner in this study. Alanine transaminase was elevated in a dose dependent manner. Histopathological changes were seen in all doses and duration of administration of confam. 1960 roots showed these changes with increasing duration of use and doses. These results further suggest that these bitters cause some degree of hepatic damage and should be used with care, in moderate amounts and with proper monitoring of liver function indices.
Keywords
Herbal Bitters, Hepatic Damage, Wister Albino Rats, Histopathological Changes
To cite this article
George Adieboye Oforibika, Diepiriye Adokiye Oforibika, Evaluation of Liver Toxicity of Three Different Herbal Bitters (Confam, G. Winco and 1960 Roots) on Wister Albino Rats, Pharmaceutical Science and Technology. Vol. 4, No. 1, 2020, pp. 11-16. doi: 10.11648/j.pst.20200401.12
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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